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Volume 23 , Issue 1
January/February 2003
Pages 47–55

Clinical and Histologic Evaluation of Human Intrabony Defects Treated with an Enamel Matrix Protein Derivative Combined with a Bovine-Derived Xenograft

Anton Sculean, DMD, Dr Med Dent, MS, PhD/Péter Windisch, DMD/Tibor Keglevich, DMD/Giovanni Carlo Chiantella, DDS, MS/István Gera, DMD, PhD/Nicolaos Donos, DDS, MS, PhD

PMID: 12617368
DOI: 10.11607/prd.00.0509

The purpose of the present case report study was to clinically and histologically evaluate the healing of deep intrabony defects following treatment with either a combination of an enamel matrix protein derivative (EMD) and a bovine-derived xenograft (BDX) or with BDX alone. Three female patients with generalized marginal periodontitis and presenting one advanced intrabony defect each were treated with either a combination of EMD + BDX (two defects) or with BDX alone (one defect). The postoperative healing was uneventful in all three cases. Six months after surgery, a gain of clinical attachment was measured at all treated sites. The histologic examination revealed that all three defects healed with a new connective tissue attachment (ie, new cellular cementum with inserting collagen fibers) and new bone. Most of the BDX particles were surrounded by a bonelike tissue. No direct contact between BDX particles and the root surface (cementum or dentin) was observed. Within their limits, the present data indicate that treatment with either EMD + BDX or with BDX alone may enhance the formation of new connective tissue attachment and new bone in human intrabony defects. (Int J Periodontics Restorative Dent 2003;23:47–55.)

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